GSK3739936 [1803444-21-4]

MedChem Express

GSK3739936 [1803444-21-4]

10

1803444-21-4

Research Use Only

C34H43FN2O4

562.71

GSK3739936 (BMS-986180) is a potent HIV-1 allosteric integrase inhibitor with an IC50 value of 11.1 nM and an EC50 value of 1.7 nM. GSK3739936 is also a weak CYP inhibitor (IC50>24.3 microM). GSK3739936 shows favorable pharmacokinetic property in preclinical species with rapid absorption, low to moderate clearance and excellent oral bioavailability[1].

CC1=NC(C)=C(C(N2CCC(C)(CC2)C)=C1[C@@H](C(O)=O)OC(C)(C)C)C3=CC=C(C=C3)OCCC4=CC=C(C=C4)F

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