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GSK484 hydrochloride [1652591-81-5]

GSK484 hydrochloride [1652591-81-5]

TQ0067
TargetMol Chemicals
CAS Number1652591-81-5
Product group Chemicals
Estimated Purity99.62%
Molecular Weight510.03
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    GSK484 hydrochloride [1652591-81-5]
  • Delivery Days Customer
    9
  • CAS Number
    1652591-81-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.62%
  • Molecular Formula
    C27H32ClN5O3
  • Molecular Weight
    510.03
  • Scientific Description
    GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor. It binds to PAD4 with high affinity, with IC50 of 250 and 50 nM in the presence and absence of 2 mM calcium, respectively. GSK484 promotes the radiosensitivity of colorectal cancer (CRC) and inhibits NET formation in vitro and in vivo.
  • SMILES
    Cl.COc1cc(cc2nc(-c3cc4ccccc4n3CC3CC3)n(C)c12)C(=O)N1CC[C@@H](O)[C@@H](N)C1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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