GSK8814 [1997369-78-4]

TargetMol Chemicals

GSK8814 [1997369-78-4]

114

1997369-78-4

Chemical

Research Use Only

GSK8814

C28H35F2N5O3

527.61

GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan). GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s: 7.3 and 4.6).

3 years

CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12

-20°C

12352200