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GSTZ1 antibody [N1C3]

GTX106109
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetGSTZ1
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Overview

  • Supplier
    GeneTex
  • Product Name
    GSTZ1 antibody [N1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.98 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2954
  • Target name
    GSTZ1
  • Target description
    glutathione S-transferase zeta 1
  • Target synonyms
    glutathione S-alkyltransferase; glutathione S-aralkyltransferase; glutathione S-aryltransferase; glutathione transferase zeta 1; GSTZ1-1; MAAI; MAAID; MAI; maleylacetoacetate isomerase; maleylacetone isomerase; S-(hydroxyalkyl)glutathione lyase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO43708
  • Protein Name
    Maleylacetoacetate isomerase
  • Scientific Description
    This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Wang Q et al., 2021 Apr 30, Cell Death Dis
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  • GSTZ1-1 downregulates Wnt/beta-catenin signalling in hepatocellular carcinoma cells. Lei C et al., 2020 Jan, FEBS Open Bio
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  • GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Li J et al., 2019 Oct 30, J Exp Clin Cancer Res
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