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Guanfacine-13C,15N3 [1189924-28-4]

Guanfacine-13C,15N3 [1189924-28-4]

T35591
TargetMol Chemicals
CAS Number1189924-28-4
Product group Chemicals
Molecular Weight250.06
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Guanfacine-13C,15N3 [1189924-28-4]
  • Delivery Days Customer
    44
  • CAS Number
    1189924-28-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Guanfacine-13C,15N3
  • Molecular Formula
    C9H9Cl2N3O
  • Molecular Weight
    250.06
  • Scientific Description
    Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an alpha2-adrenergic receptor (alpha2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively, for stimulated [35S]GTPgammaS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.3It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.4Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).
  • Shelf life instruction
    3 years
  • SMILES
    [15NH2][13C](=[15NH])[15NH]C(=O)Cc1c(Cl)cccc1Cl
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200