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Guggulsterone

M13379
AbMole BioScience
CAS Number95975-55-6
Product group Chemicals
Molecular Weight312.45
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Guggulsterone
  • Delivery Days Customer
    9
  • CAS Number
    95975-55-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C21H28O2
  • Molecular Weight
    312.45
  • Scientific Description
    Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. Guggulsterone is a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 uM for Z- and E-Guggulsterone, respectively. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
  • SMILES
    CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
  • Storage Instruction
    4°C, protect from light
  • UNSPSC
    12352200