Guggulsterone
M13379
CAS Number95975-55-6
Product group Chemicals
Molecular Weight312.45
Overview
- SupplierAbMole BioScience
- Product NameGuggulsterone
- Delivery Days Customer9
- CAS Number95975-55-6
- Category SupplierChemical
- CertificationResearch Use Only
- Molecular FormulaC21H28O2
- Molecular Weight312.45
- Scientific DescriptionGuggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. Guggulsterone is a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 uM for Z- and E-Guggulsterone, respectively. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
- SMILESCC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
- Storage Instruction4°C, protect from light
- UNSPSC12352200
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![Guggulsterone [95975-55-6]](https://www.targetmol.com/group3/M00/02/5D/CgoaEGY7MQaEGzAwAAAAAIS9GIY371.png)
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Molecular Weight312.45
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