GW274150 (dihydrochloride) [438542-17-7]

MedChem Express

GW274150 (dihydrochloride) [438542-17-7]

14

438542-17-7

Research Use Only

C8H19Cl2N3O2S

292.23

GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 microM; Kd=40 nM) and rat iNOS (ED50=1.15 microM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation[1][2][3].

OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl

12352200