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ProductsBack/GW280264X [866924-39-2]

GW280264X [866924-39-2]

Research Use Only
HY-115670
MedChem Express
CAS Number866924-39-2
DownloadMSDS
Product group Chemicals
Estimated Purity98.28
Molecular Weight575.72
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Overview

  • Supplier
    MedChem Express
  • Product Name
    GW280264X [866924-39-2]
  • Delivery Days Customer
    10
  • CAS Number
    866924-39-2
  • Certification
    Research Use Only
  • Estimated Purity
    98.28
  • Molecular Formula
    C28H41N5O6S
  • Molecular Weight
    575.72
  • Scientific Description
    GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2].
  • SMILES
    O=C(OCC1=CC=CC=C1)NCCCC[C@H](NC([C@H](CC(C)C)[C@@H](N(C=O)O)CCC)=O)C(NC2=NC=CS2)=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200