GW7845 [196809-22-0]
HY-121746
CAS Number196809-22-0
Product group Chemicals
Molecular Weight500.54
Overview
- SupplierMedChem Express
- Product NameGW7845 [196809-22-0]
- Delivery Days Customer5
- CAS Number196809-22-0
- CertificationResearch Use Only
- Molecular FormulaC29H28N2O6
- Molecular Weight500.54
- Scientific DescriptionGW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARgamma agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 microM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].
- SMILESO=C([C@H](CC1=CC=C(C=C1)OCCC2=C(OC(C3=CC=CC=C3)=N2)C)NC4=CC=CC=C4C(OC)=O)O
- UNSPSC12352200