H2-005 [1060478-12-7]

MedChem Express

H2-005 [1060478-12-7]

9

1060478-12-7

Research Use Only

C24H32N4O4

440.54

H2-005 is a compound that selectively inhibits diacylglycerol acyltransferase 2 (DGAT2) and has the activity to inhibit triacylglycerol synthesis in hepatocytes and preadipocytes. H2-005 significantly reduces triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. H2-005 exhibits specific inhibitory activity in DGAT2-overexpressing HEK293 cells. H2-005 almost completely inhibits lipid droplet formation in 3T3-L1 cells when co-treated with a DGAT1 inhibitor. H2-005 will contribute to DGAT2-related lipid metabolism research and the development of drugs to inhibit metabolic diseases[1].

O=C(C1=C(C2=C(N1CCC(C)C)N=CC(NC(CC)CC)=C2)NC(C3=CC=CO3)=O)OC

12352200