H3B-5942

MedChem Express

H3B-5942 [2052128-15-9]

10

2052128-15-9

Research Use Only

99.73

C31H34N4O2

494.63

H3B-5942 is a selective, irreversible and orally active estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERalpha by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. H3B-5942 reduces ERalpha target gene GREB1, shows potent antitumor activity both in multiple cell lines or animals bearing ERalphaWT or ERalpha mutations[1].

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC/C=C/C(N(C)C)=O)C=C2)\C3=CC(C=NN4)=C4C=C3

-20°C,2°C to 8°C

12352200