H3B-5942 [2052128-15-9]
HY-112611
Overview
- SupplierMedChem Express
- Product NameH3B-5942 [2052128-15-9]
- Delivery Days Customer10
- CAS Number2052128-15-9
- CertificationResearch Use Only
- Estimated Purity98%
- Molecular FormulaC31H34N4O2
- Molecular Weight494.63
- Scientific DescriptionH3B-5942 is a selective, irreversible and orally active estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERalpha by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. H3B-5942 reduces ERalpha target gene GREB1, shows potent antitumor activity both in multiple cell lines or animals bearing ERalphaWT or ERalpha mutations.
- SMILESCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC/C=C/C(N(C)C)=O)C=C2)\C3=CC(C=NN4)=C4C=C3
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200