hAChE/hBACE-1-IN-1

MedChem Express

hAChE/hBACE-1-IN-1

14

Research Use Only

C23H23N5O2S

433.53

hAChE/hBACE-1-IN-1 (compounds 5d) is an orally active inhibitor of hAChE with blood-brain permeability. hAChE/hBACE-1-IN-1 inhibits hAChE and hBACE-1 with IC50 values of 0.076 and 0.23 microM, respectively. hAChE/hBACE-1-IN-1 inhibits Abeta1-42 aggregation and improves mouse learning and memory ability. hAChE/hBACE-1-IN-1 can be used to research in Alzheimers disease[1].

O=C(CSC1=NN=C(C2=CC=CC(C#N)=C2)O1)NC3CCN(CC3)CC4=CC=CC=C4

12131703