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Halobetasol propionate
T6529
CAS Number66852-54-8
Product group Chemicals
Molecular Weight484.96
Overview
- SupplierTargetMol Chemicals
- Product NameHalobetasol propionate
- Delivery Days Customer9
- CAS Number66852-54-8
- Category SupplierChemical
- Chemical NameHalobetasol propionate
- Molecular FormulaC25H31ClF2O5
- Molecular Weight484.96
- Scientific DescriptionHalobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.
- Shelf life instruction3 years
- SMILESO(C(CC)=O)[C@@]1(C(CCl)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[H])[H]
- Storage Instruction-20°
- UNSPSC12352200
References
- Mohandas S, et al. Indian J Dermatol Venereol Leprol, 2009, 75(2), 186-187.Read more