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Halofenate [26718-25-2]

HY-14998
MedChem Express
CAS Number26718-25-2
Product group Chemicals
Molecular Weight415.79
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Halofenate [26718-25-2]
  • Delivery Days Customer
    5
  • CAS Number
    26718-25-2
  • Certification
    Research Use Only
  • Molecular Formula
    C19H17ClF3NO4
  • Molecular Weight
    415.79
  • Scientific Description
    Halofenate, structurally akin to clofibrate, was evaluated in hypertriglyceridemic patients over 6-week periods in a controlled, double-blind crossover trial. It effectively reduced serum triglycerides by 50%, with minimal impact on serum cholesterol levels. Additionally, it lowered serum uric acid by 30% and exhibited uricosuric effects independent of glomerular filtration rate. Halofenate was associated with a significant increase in plasma thyroxine (T4), accompanied by a decrease in protein-bound iodine and T4 by column. In vitro studies confirmed its ability to displace T4 from thyroid-binding proteins, suggesting a thyroxine-displacing effect, which could influence thyroid function in vivo[1].
  • SMILES
    CC(NCCOC(C(C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2)=O)=O
  • UNSPSC
    12131703