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Halofuginone hydrobromide

T3524
TargetMol Chemicals
CAS Number64924-67-0
Product group Chemicals
Molecular Weight495.59
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Halofuginone hydrobromide
  • Delivery Days Customer
    9
  • CAS Number
    64924-67-0
  • Category Supplier
    Chemical
  • Chemical Name
    Halofuginone hydrobromide
  • Molecular Formula
    C16H17BrClN3O3.HBr
  • Molecular Weight
    495.59
  • Scientific Description
    Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
  • Shelf life instruction
    3 years
  • SMILES
    Br.O[C@@H]1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
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