Anti-Ms CD79b Purified

EXBIO

Anti-Ms CD79b Purified

7

Flow cytometry: Recommended dilution: 1 microg/ml.

Flow Cytometry, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

HM79

1 mg/ml

IgG2

CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Human, Mouse

2°C to 8°C

12352203