Haptoglobin, Phenotype 2-1 [9087-69-8]

Athens Research

Haptoglobin, Phenotype 2-1 [9087-69-8]

9

ELISA, Protein Chemistry, Inflammation, Sickle Cell Anemia, Glycosylation, Stroke, Central Nervous System Injury, Diabetes, Cardiovascular Disease, In Vitro Diagnostic, Iron Metabolism, Cancer

Research Use Only

≥95% by SDS-PAGE

Haptoglobin

Haptoglobin 2-1 (Hp2-1) is a heterozygous phenotype of the haptoglobin protein, formed by the combination of Hp1 and Hp2 alleles. This plasma glycoprotein serves a critical function by binding free hemoglobin released during red blood cell breakdown, preventing oxidative damage and iron loss while facilitating its removal via the reticuloendothelial system. Hp2-1 represents an intermediate phenotype between Hp1-1 and Hp2-2 in terms of functionality and disease association. While Hp1-1 offers superior antioxidant capacity and hemoglobin binding efficiency, Hp2-1 provides moderate protection. This has significant clinical implications, particularly in diabetes, where Hp2-1 carriers have lower cardiovascular disease risk than Hp2-2 individuals but higher risk than Hp1-1 carriers. Diagnostically, haptoglobin phenotyping via tests like the Haptoglobin Typing ELISA helps identify diabetic patients who might benefit from specific interventions, such as vitamin E supplementation. Haptoglobin testing also aids in diagnosing and monitoring hemolytic anemia and other conditions involving accelerated red blood cell destruction.

more then 1 year

Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

-20C

41116100