Harman-d3 [1216708-84-7]

MedChem Express

Harman-d3 [1216708-84-7]

5

1216708-84-7

Research Use Only

C12H7D3N2

185.24

Harman-d3 is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC50=7 microM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and alpha2-adrenergic receptor of 24 microM, 2.8 microM, 0.5 microM, 5 microM, and 18 microM, respectively. Harmane also inhibits haloperidol and serotonin, with IC50 values of 163 microM and 101 microM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF)[1][2][3][4][5][6].

[2H]C([2H])(C1=NC=CC2=C1NC3=C2C=CC=C3)[2H]

12352200