Harmane

MedChem Express

Harmane [486-84-0]

10

486-84-0

Research Use Only

99.91

C12H10N2

182.226

Harmane is a benzodiazepine receptor inhibitor (IC50=7 microM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and alpha2-adrenergic receptor of 24 microM, 2.8 microM, 0.5 microM, 5 microM, and 18 microM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF)[1][2][3][4][5][6].

CC1=NC=CC2=C1NC3=C2C=CC=C3

-20°C,2°C to 8°C

12352200