Harmine [442-51-3]

Chemodex

Harmine [442-51-3]

2

442-51-3

Research Use Only

>98%

Warning

C13H12N2O

212.25

Chemical. CAS: 442-51-3. Formula: C13H12N2O. MW: 212.25. Harmine is a fluorescent beta-carboline alkaloid. It is a useful fluorescent pH indicator which shows a color change from pH 7.2 (blue fluorescence) to pH 8.9 (yellow fluorescence). It is used with the radioisotope carbon-11 in positron emission tomography neuroimaging to examine its binding to MAO-A. It has several targets and biological activities. It is a potent ATP-competitive and selective inhibitor of DYRK1A, DYRK2 and DYRK3, a competitive and reversible monoamine oxidase inhibitor (MAOI) that reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B and a acetylcholinesterase inhibitor (AChEI). It has shown antiviral, antimalarial, anticancer, antidiabetic and osteoclastogenesis activities. - Harmine is a fluorescent beta-carboline alkaloid. It is a useful fluorescent pH indicator which shows a color change from pH 7.2 (blue fluorescence) to pH 8.9 (yellow fluorescence). It is used with the radioisotope carbon-11 in positron emission tomography neuroimaging to examine its binding to MAO-A. It has several targets and biological activities. It is a potent ATP-competitive and selective inhibitor of DYRK1A, DYRK2 and DYRK3, a competitive and reversible monoamine oxidase inhibitor (MAOI) that reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B and a acetylcholinesterase inhibitor (AChEI). It has shown antiviral, antimalarial, anticancer, antidiabetic and osteoclastogenesis activities.

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

-20°C,2°C to 8°C

12162000