Harzianopyridone [137813-88-8]

TargetMol Chemicals

Harzianopyridone [137813-88-8]

999

137813-88-8

Research Use Only

Harzianopyridone

C14H19NO5

281.308

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 microM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 microM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 microM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 microg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

3 years

COc1[nH]c(=O)c(C(=O)[C@@H](C)C\C=C\C)c(O)c1OC

-20°C

12352200