Bio-Connect

HAT-SIL-TG-1&AT

HY-149257
MedChem Express
Molecular Weight1236.36
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    HAT-SIL-TG-1&AT [2973282-50-5]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C60H69N17O11S
  • Molecular Weight
    1236.36
  • Scientific Description
    HAT-SIL-TG-1&AT is a Janus tyrosine kinase (JAK) inhibitor with antitumor effects. HAT-SIL-TG-1&AT is the hypoxia-activated prodrug, witch inhibits JAK-STAT signaling in tumor tissue. And HAT-SIL-TG-1&AT inhibits HEL cells proliferation and downregulated phosphorylated STAT3/5 under hypoxic conditions[1].
  • SMILES
    CC1=CC(COC(N2C=C(C(C3=NC4=C(N3)C=CC(CN5CCOCC5)=C4)=N2)NC(NC6CC6)=O)=O)=C(C(COC(N7CCN(CC7)C8=CC=C(C=C8)NC9=NC=C(C(NC%10=CC(S(=O)(NC(C)(C)C)=O)=CC=C%10)=N9)C)=O)=C1)OCC%11=CN=C(N%11C)[N+]([O-])=O
  • UNSPSC
    12131703