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HBT1 [489408-02-8]

HY-122742
MedChem Express
CAS Number489408-02-8
Product group Chemicals
Estimated Purity99.83
Molecular Weight386.39
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Overview

  • Supplier
    MedChem Express
  • Product Name
    HBT1 [489408-02-8]
  • Delivery Days Customer
    10
  • CAS Number
    489408-02-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.83
  • Molecular Formula
    C16H17F3N4O2S
  • Molecular Weight
    386.39
  • Scientific Description
    HBT1 is an effective AMPA receptor AMPA-R potentiator. HBT1 specifically binds to the ligand-binding domain (LBD) of AMPAR and enhances receptor activity only when AMPA is present., HBT1 has almost no agonistic effect (i.e., reaching the optimal concentration, and then the efficacy decreases as the concentration continues to increase) compared with traditional AMPA-R potentiator, avoiding the bell-shaped reaction of brain-derived neurotrophic factor (BDNF) production in primary neurons. HBT1 can be applicable to a wider range of neurological and psychiatric diseases (such as depression, Alzheimers disease, etc.)[1].
  • SMILES
    O=C(NC1=C(C(N)=O)C(CCCC2)=C2S1)CN3N=C(C(F)(F)F)C=C3C
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703

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