HCV-N-G2b (residues 2-119), Hepatitis C Virus Nucleocapsid Genotype 2b, recombinant, E. coli

Jena Bioscience

HCV-N-G2b (residues 2-119), Hepatitis C Virus Nucleocapsid Genotype 2b, recombinant, E. coli

5

Western Blot, ELISA

Research Use Only

>95%

The protein contains the HCV core nucleocapsid immunodominant regions, amino acids: 1-102. The protein is fused to a GST-tag at the N-Terminus. Hepatitis C Virus core proteins are purified by proprietary chromatographic techniques. Background: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.

-20°C

12352202