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HCV-N-G3b (residues 2-119), Hepatitis C Virus Nucleocapsid Genotype 3b, recombinant, E. coli

Research Use Only
PR-1136
Jena Bioscience
ApplicationsWestern Blot, ELISA
Product group Proteins / Signaling Molecules
€ 391,00
100 ug
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Overview

  • Supplier
    Jena Bioscience
  • Product Name
    HCV-N-G3b (residues 2-119), Hepatitis C Virus Nucleocapsid Genotype 3b, recombinant, E. coli
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Scientific Description
    The protein contains the HCV core nucleocapsid immunodominant regions, amino acids: 1-102. Hepatitis C Virus core proteins are purified by proprietary chromatographic techniques. Background: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202