HDAC-IN-46 [2562386-85-8]

MedChem Express

HDAC-IN-46 [2562386-85-8]

10

2562386-85-8

Research Use Only

C22H30N8O2

438.53

HDAC-IN-46 (compound 12c) is a potent HDAC inhibitor with an IC50 value of 0.21 microM and 0.021 microM for HDAC1 and HDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest and apoptosis. HDAC-IN-46 can be used for researching triple-negative breast cancer (TNBC)[1].

O=C(NO)CCCCCCCN1N=NC(C2=CC=C(C3=C(CC)N=C(N)N=C3N)C=C2)=C1

12131703