HDAC4 antibody [N3C1], Internal
GTX110231
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHDAC4
Overview
- SupplierGeneTex
- Product NameHDAC4 antibody [N3C1], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration2.1 mg/ml
- ConjugateUnconjugated
- Gene ID9759
- Target nameHDAC4
- Target descriptionhistone deacetylase 4
- Target synonymsAHO3; BDMR; HA6116; HD4; HDAC-4; HDACA; HDAC-A; histone deacetylase 4; histone deacetylase A
- HostRabbit
- IsotypeIgG
- Protein IDP56524
- Protein NameHistone deacetylase 4
- Scientific DescriptionHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation. Zhao B et al., 2022, Front PharmacolRead more
- GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. Lai CY et al., 2018 Jun, NeuropharmacologyRead more
- Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. Lin TB et al., 2016 Apr, J Pineal ResRead more
- Modulation of Nerve Injury-induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats. Lin TB et al., 2015 Jul, AnesthesiologyRead more