Bio-Connect

HDAC4 antibody [N3C1], Internal

GTX110231
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetHDAC4
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Overview

  • Supplier
    GeneTex
  • Product Name
    HDAC4 antibody [N3C1], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    2.1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9759
  • Target name
    HDAC4
  • Target description
    histone deacetylase 4
  • Target synonyms
    AHO3; BDMR; HA6116; HD4; HDAC-4; HDACA; HDAC-A; histone deacetylase 4; histone deacetylase A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP56524
  • Protein Name
    Histone deacetylase 4
  • Scientific Description
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Catalpol ameliorates CFA-induced inflammatory pain by targeting spinal cord and peripheral inflammation. Zhao B et al., 2022, Front Pharmacol
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  • GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription. Lai CY et al., 2018 Jun, Neuropharmacology
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  • Melatonin relieves neuropathic allodynia through spinal MT2-enhanced PP2Ac and downstream HDAC4 shuttling-dependent epigenetic modification of hmgb1 transcription. Lin TB et al., 2016 Apr, J Pineal Res
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  • Modulation of Nerve Injury-induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats. Lin TB et al., 2015 Jul, Anesthesiology
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