HDAC6 degrader-1

MedChem Express

HDAC6 degrader-1 [2439058-23-6]

10

2439058-23-6

Research Use Only

98.59

C40H45N9O9

795.84

HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation [1] .

O=C(C1=CC=C(CN(CCCCC2=CN(CCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1)NO

2°C to 8°C

12352200