HDAC6-IN-5 [2413603-15-1]

MedChem Express

HDAC6-IN-5 [2413603-15-1]

10

2413603-15-1

Research Use Only

C20H14BrN3O2

408.25

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 microM. HDAC6-IN-5 exhibits strong inhibitory activity against Abeta1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 microM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].

O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO

12131703