Bio-Connect

HDAC/HSP90-IN-4

HY-146212
MedChem Express
Product group Chemicals
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    MedChem Express
  • Product Name
    HDAC/HSP90-IN-4
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    These compounds have strong hdac and hsp90 inhibitory activities. Compound 20 (HDAC ic50 = 194 nm; Hsp90 alpha Ic50 = 153 nm) and compound 26 ((HDAC ic50= 360 nm; Hsp90 alpha Ic50 = 77 nm) shows the strongest HDAC and HSP90 alpha Inhibitory activity. Both compounds can induce hsp90 expression and down regulate hsp90 client proteins, which play an important role in regulating the survival and invasion of cancer cells.
  • SMILES
    CC(C1=CC(C(N(C2=CC=C(C=C2)NC(CC(NO)=O)=O)C)=O)=C(C=C1O)O)C.[n].[n=6,7]
  • UNSPSC
    12131703