hDHODH-IN-12

MedChem Express

hDHODH-IN-12

14

Research Use Only

C22H15F3N4O3

440.37

hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 microM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer[1].

O=C(C1=CNC2=C1C=C(NC3=CC=C([N+]([O-])=O)C=C3)C=C2)NC4=CC=CC(C(F)(F)F)=C4

12131703