Heclin, HECT E3 Ubiquitin Ligase Inhibitor
BS-60248C
Estimated Purity98.0
Product group Chemicals
Overview
- SupplierBioss
- Product NameHeclin, HECT E3 Ubiquitin Ligase Inhibitor
- Delivery Days Customer16
- CertificationResearch Use Only
- Estimated Purity98.0
- Scientific DescriptionHeclin is a selective HECT E3 ubiquitin ligase inhibitor, inhibits Nedd4, Smurf2 and WWP1 with IC50 6.3, 6.8 and 6.9 microM respectively. It is selective for HECT-mediated over RING-mediated ubiquitination. Heclin does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys. It kills HEK293 cells growing in culture, consistent with an essential role for HECT ligase activity in mammalian cells.
- Storage Instruction-20°C
- UNSPSC51202000