Hederacoside C [14216-03-6]

Chemodex

Hederacoside C [14216-03-6]

10

6.1

14216-03-6

Research Use Only

>98%

Warning

C59H96O26

1221.38

Chemical. CAS: 14216-03-6. Formula: C59H96O26. MW: 1221.38. Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-alpha, IL-1beta, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-kappa (p65 and IkappaBalpha) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and IkappaBalpha. - Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-alpha, IL-1beta, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-kappa (p65 and IkappaBalpha) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and IkappaBalpha.

O=C(O[C@H](O[C@@H]1CO[C@H](O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]2O[C@@](O[C@H]3C)([H])[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]1O)[C@@]4(CC5)CC[C@]6(C)C([C@]4([H])CC5(C)C)=CC[C@@]7([H])[C@@]6(C)CC[C@]8([H])[C@]7(C)CC[C@H](O[C@@](OC[C@@H]9O)([H])[C@]([C@H]9O)([H])O[C@H](O[C@H]%10C)[C@H](O)[C@H](O)[C@H]%10O)[C@@]8(C)CO

2°C to 8°C,RT

2811

12352200