Heparan Sulphate Proteoglycan(A7L6), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

Heparan Sulphate Proteoglycan(A7L6), CF405S conjugate, 0.1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

A7L6

0.1 mg/ml

Other Conjugate

HSPG2

heparan sulfate proteoglycan 2

basement membrane-specific heparan sulfate proteoglycan core protein; endorepellin (domain V region); HSPG; perlecan proteoglycan; PLC; PRCAN; SJA; SJS; SJS1

Rat

IgG2a

Basement membrane-specific heparan sulfate proteoglycan core protein

This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecans strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Fish, Human, Monkey, Mouse, Porcine, Rat

2°C to 8°C

12352203