HIF-C2 --- HIF-2 Inhibitor

Bioss

HIF-C2 --- HIF-2 Inhibitor [1422955-31-4]

16

Research Use Only

98.0

HIF-C2 is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2). It binds within the internal cavity of HIF-2alpha PAS-B (Kd of 81 nM) and disrupts heterodimerization of the full-length HIF-2 transcription factor. HIF-C2 functions effectively as a HIF-2 inhibitor in living cells, disrupting HIF-2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF-C2 is selective for the HIF-2 isoform and has no activity to antagonize HIF-1. HIF-C2 provides an opportunity to delineate differences in HIF-1 and HIF-2 biology and serves as an entry point for development of HIF-2 inhibitor drugs for treating diseases, including renal cell carcinomas.

-20°C

51202000