Higenamine

MedChem Express

Higenamine [5843-65-2]

10

5843-65-2

Research Use Only

98.91

C16H17NO3

271.31

Higenamine (Norcoclaurine), a beta2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a alpha1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor ( IC 50 =1.47 microM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor ( beta2-AR ). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1beta-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] .

OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O

2°C to 8°C

12352200