ProductsBack/Histamine H2 Receptor antibody [N1], N-term

Histamine H2 Receptor antibody [N1], N-term

Name: Histamine H2 Receptor antibody [N1], N-term
SKU: GTX108152_G10
Availability: BackOrder

GTX108152

ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Rat

TargetHRH2

Overview

Supplier
GeneTex
Product Name
Histamine H2 Receptor antibody [N1], N-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.75 mg/ml
Conjugate
Unconjugated
Gene ID3274
Target name
HRH2
Target description
histamine receptor H2
Target synonyms
H2R, HH2R, histamine H2 receptor, gastric receptor 1, gastric receptor I
Host
Rabbit
Isotype
IgG
Protein IDP25021
Protein Name
Histamine H2 receptor
Scientific Description
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Reactivity
Human, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Crouchet E, Bandiera S, Fujiwara N, et al. A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery. Nat Commun. 2021,12(1):5525. doi: 10.1038/s41467-021-25468-9
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Liu X, Kumagai G, Wada K, et al. Suppression of osteogenic differentiation in mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament by a histamine-2-receptor antagonist. Eur J Pharmacol. 2017,810:156-162. doi: 10.1016/j.ejphar.2017.07.013
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Adderley SP, Zhang XE, Breslin JW. Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction. Microcirculation. 2015,22(4):237-48. doi: 10.1111/micc.12189
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Kurtz KH, Moor AN, Souza-Smith FM, et al. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation. 2014,21(7):593-605. doi: 10.1111/micc.12138
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Frei R, Ferstl R, Konieczna P, et al. Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol. 2013,132(1):194-204. doi: 10.1016/j.jaci.2013.01.013
Read this paper