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Histone H1.2 antibody

Research Use Only
GTX122561
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetH1-2
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H1.2 antibody
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.88 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3006
  • Target name
    H1-2
  • Target description
    H1.2 linker histone, cluster member
  • Target synonyms
    H1 histone family, member 2; H1.2; H1C; H1F2; H1s-1; HIST1H1C; histone 1, H1c; histone cluster 1 H1 family member c; histone cluster 1, H1c; histone H1.2; histone H1c; histone H1d; histone H1s-1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing. Uggenti C et al., 2020 Dec, Nat Genet
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  • MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation. Li YH et al., 2020, Front Oncol
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  • Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes. Xu H et al., 2019 Dec, PLoS Pathog
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  • Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair. Li Z et al., 2018 Jul, Cell Res
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