Histone H1.2 antibody
GTX122561
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetH1-2
Overview
- SupplierGeneTex
- Product NameHistone H1.2 antibody
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.88 mg/ml
- ConjugateUnconjugated
- Gene ID3006
- Target nameH1-2
- Target descriptionH1.2 linker histone, cluster member
- Target synonymsH1 histone family, member 2; H1.2; H1C; H1F2; H1s-1; HIST1H1C; histone 1, H1c; histone cluster 1 H1 family member c; histone cluster 1, H1c; histone H1.2; histone H1c; histone H1d; histone H1s-1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionHistones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing. Uggenti C et al., 2020 Dec, Nat GenetRead more
- MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation. Li YH et al., 2020, Front OncolRead more
- Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes. Xu H et al., 2019 Dec, PLoS PathogRead more
- Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair. Li Z et al., 2018 Jul, Cell ResRead more