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ProductsBack/Histone H2A.vS137ph (phospho Ser137) antibody
Western blot using GeneTexs affinity purified anti-histone H2AvD pS137 antibody shows detection of a band at ~15 kDa corresponding to phosphorylated H2AvD (lane 2 arrow-head). Lanes contain either mock-irradiated (lane 1) or 4000-RAD gamma irradiated (lane 2) Drosophila melanogaster (3rd instar) larvae brain WC lysate separated on by SDS-PAGE and transferred to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:500. Washes and reaction with secondary antibody followed incubation. Use HRP conjugated Gt-a-Rabbit IgG [H&L] MX and ECL for detection.
Western blot using GeneTexs affinity purified anti-histone H2AvD pS137 antibody shows detection of a band at ~15 kDa corresponding to phosphorylated H2AvD (lane 2 arrow-head). Lanes contain either mock-irradiated (lane 1) or 4000-RAD gamma irradiated (lane 2) Drosophila melanogaster (3rd instar) larvae brain WC lysate separated on by SDS-PAGE and transferred to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:500. Washes and reaction with secondary antibody followed incubation. Use HRP conjugated Gt-a-Rabbit IgG [H&L] MX and ECL for detection.
Western blot using GeneTexs affinity purified anti-histone H2AvD pS137 antibody shows detection of a band at ~15 kDa corresponding to phosphorylated H2AvD (lane 2 arrow-head). Lanes contain either mock-irradiated (lane 1) or 4000-RAD gamma irradiated (lane 2) Drosophila melanogaster (3rd instar) larvae brain WC lysate separated on by SDS-PAGE and transferred to nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:500. Washes and reaction with secondary antibody followed incubation. Use HRP conjugated Gt-a-Rabbit IgG [H&L] MX and ECL for detection.

Histone H2A.vS137ph (phospho Ser137) antibody

Research Use Only
GTX48733
GeneTex
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityDrosophila
TargetHis2Av
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Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H2A.vS137ph (phospho Ser137) antibody
  • Delivery Days Customer
    9
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID43229
  • Target name
    His2Av
  • Target description
    Histone H2A variant
  • Target synonyms
    *i H2av; 5499; CG5499; CG5499-PA; CG5499-PB; dHis2Av; Dmel\CG5499; Dmel_CG5499; gammaH2AV; gamma-H2AV; gamma-H2AvD; gammaH2Ax; gamma-HIS2AV; H2A; H2A.F/Z; H2A.V; H2A.X; H2A.Z; H2AV; H2AV_DROM; H2avD; H2AX; H2AZ; HIS; His2; His2A; His2AV; HIS2AVD; His2Av-PA; His2Av-PB; HisH2Av; Hist; Hist2av; histone; histone 2A; histone H2A; histone H2A.v; histone H2Av; histone2A; Histone-2A; histone2Av; Histone-2av; histone2AvD; l(3)05146; l(3)810; l(3)97Dd; l(3)L1602
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Phosphorylated
  • Scientific Description
    Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX knock out mice have an increased incidence of cancer.
  • Reactivity
    Drosophila
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Metabolically active and polyploid renal tissues rely on graded cytoprotection to drive developmental and homeostatic stress resilience. Burbridge K et al., 2021 Apr 15, Development
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