HIV-1 inhibitor-24 [2475658-75-2]

MedChem Express

HIV-1 inhibitor-24 [2475658-75-2]

10

2475658-75-2

Research Use Only

C26H19N5O2

433.46

HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 microM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1].

N#CC1=CC=C(C2=CC=C([C@@H](C3=NC(NC4=CC=C(C#N)C=C4)=NC=C3)O)C(OC)=C2)C=C1

12131703