HIV-1 inhibitor-40

MedChem Express

HIV-1 inhibitor-40 [2789676-44-2]

10

Research Use Only

C25H18N6O2

434.45

HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 microM and 4.51 microM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity[1].

NC1=NC(NC2=CC=C(C=C2)C#N)=NC(OC(C=CC(C3=CC=C(C=C3)C#N)=C4)=C4OC)=C1

12131703