HIV-1 inhibitor-58

MedChem Express

HIV-1 inhibitor-58 [3034064-68-8]

14

Research Use Only

C26H24N6O2

452.51

HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC50 less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 (IC50: 2.06 microM, 1.91 microM). HIV-1 inhibitor-58 can be used for HIV infection reserch[1].

CC1=CC(C#N)=CC(C)=C1OC2=C3CN(CCC3=NC(NC4=CC=C(C=C4)C#N)=N2)C(CC)=O

12131703