HIV-1 protease-IN-4

MedChem Express

HIV-1 protease-IN-4

10

Research Use Only

C48H69N7O11

920.10

HIV-1 protease-IN-4 (Compound II-22) is a potent HIV-1 protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent[1].

COC(N[C@@H](C(C)(C)C)C(N[C@@H](CC1=CC=CC=C1)[C@@H](OC(OC(OC([C@@H](N(C)C)C(C)C)=O)C)=O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C=C2)C3=CC=CC=N3)=O)=O

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