HIV-1 TAT Clade-B, Human Immunodeficiency Virus 1 Trans-Acting Transcription factor, recombinant, E. coli

Jena Bioscience

HIV-1 TAT Clade-B, Human Immunodeficiency Virus 1 Trans-Acting Transcription factor, recombinant, E. coli

5

Research Use Only

>90%

Recombinant HIV-1 TAT produced in E. coli is a single, non-glycosylated, polypeptide chain containing 86 aminoacids encoded by two exons and having chain having a molecular mass of 14 kDa. Recombinant HIV-1 TAT is purified by proprietary chromatographic technique. Background: HIV belongs to the retrovirus family, distinguished by possession of a viral reverse transcriptase that transcribes viral RNA into DNA which is integrated into the host-cell genome. HIV-1 regulatory Trans-Acting Transcription factor (TAT) plays an essential role in viral replication and infectivity. In addition, during acute infection, TAT is released extracellularly by infected cells and is taken up by neighboring cells where it transactivates viral replication and increases virus infectivity.HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain(CTD) of RNA polymerase II.Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis.

-20°C

12352202