HJC0123 [1430420-02-2]

MedChem Express

HJC0123 [1430420-02-2]

5

1430420-02-2

Research Use Only

C24H16N2O3S

412.46

HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis[1].

O=C(NC1=CC=C(C2=C1)C=CS2(=O)=O)C3=CC(C4=CC=CC=C4)=NC5=CC=CC=C35

12352200