HKI-357 [848133-17-5]

TargetMol Chemicals

HKI-357 [848133-17-5]

4

848133-17-5

Research Use Only

HKI-357

98.31%

C31H29ClFN5O3

574.05

HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.

3 years

CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

-20°C

12352200