HKSOX-1 [1786411-17-3]

MedChem Express

HKSOX-1 [1786411-17-3]

5

1786411-17-3

Research Use Only

C23H6F10O11S2

712.40

HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2 -) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2 --mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2 - roles in inflammation, mitochondrial stress, and other physiological processes[1].

O=C(C1=CC=C2C(C(OC23C4=CC(F)=C(C(F)=C4OC5=C(C(OS(=O)(C(F)(F)F)=O)=C(C=C53)F)F)OS(=O)(C(F)(F)F)=O)=O)=C1)O

12162000