HL-8 [2766352-64-9]

MedChem Express

HL-8 [2766352-64-9]

5

2766352-64-9

Research Use Only

99.17

C57H59F2N11O9S2

1144.27

HL-8 is a PI3Kalpha PROTAC degrader. HL-8 promotes the ubiquitination and degradation of PI3Kalpha. HL-8 reduces pAKT levels. HL-8 has anticancer activity against colon and cervical cancer (Pink: PI3Kalpha ligand (HY-143277); Blue: E3 ligase VHL ligand (HY-138678); Black: linker (HY-W002042))[1].

COC1=NC=C(C=C1NS(=O)(C2=C(C=C(C=C2)F)F)=O)C3=CN4C(C5=NN=C(O5)C6=C(C=CC=C6)C(NCCCCCCC(N[C@@H](C(C)(C)C)C(N7C[C@H](C[C@@H]7C(NCC8=CC=C(C=C8)C9=C(N=CS9)C)=O)O)=O)=O)=O)=CN=C4C=C3

-20°C,2°C to 8°C

12352200