HLA-ABC Antibody (MHC I)

Biorbyt

HLA-ABC Antibody (MHC I)

10

Flow Cytometry, ImmunoFluorescence

Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml FACS, IF

Research Use Only

Monoclonal

Bra-23/9

Unconjugated

HLA-A

major histocompatibility complex, class I, A

HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLAA; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain

Mouse

IgG2a

HLA class I histocompatibility antigen, B-7 alpha chain

Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Immunoprecipitation of lactoperoxidase radioiodinated cell surface proteins and surface sialoglycoproteins radiolabeled by sodium metaperiodate/tritiated sodium borohydride technique confirmed the structure gp44,p12 (consisting of a 44kDa glycopeptide linked with a non-glycosylated 12kDa peptide) typical for MHC class I antigen(s) as a structure recognized by Bra23/9. Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.

Human

-20°C

12352203