Bio-Connect

HLA-ABC Antibody (MHC I)

ORB1823223
Biorbyt
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetHLA-A
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Overview

  • Supplier
    Biorbyt
  • Product Name
    HLA-ABC Antibody (MHC I)
  • Delivery Days Customer
    10
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MHC-I/8147R
  • Conjugate
    Unconjugated
  • Gene ID3105
  • Target name
    HLA-A
  • Target description
    major histocompatibility complex, class I, A
  • Target synonyms
    HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLAA; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP01889
  • Protein Name
    HLA class I histocompatibility antigen, B-7 alpha chain
  • Scientific Description
    Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class I (telomeric), class II (centromeric) and class III gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex I (MHC I ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC I is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC molecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203